Reduced bone loss in a murine model of postmenopausal osteoporosis lacking complement component 3
نویسندگان
چکیده
منابع مشابه
Prevention of Bone Loss in a Model of Postmenopausal Osteoporosis through Adrenomedullin Inhibition
Despite recent advances in the understanding and treatment options for osteoporosis, this condition remains a serious public health issue. Adrenomedullin (AM) is a regulatory peptide with reported activity on bone remodeling. To better understand this relationship we built an inducible knockout for AM. An outstanding feature of knockout mice is their heavier weight due, in part, to the presence...
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Postmenopausal osteoporotic bone loss occurs mainly due to cessation of ovarian function, a condition associated with increased free radicals. Vitamin E, a lipid-soluble vitamin, is a potent antioxidant which can scavenge free radicals in the body. In this study, we investigated the effects of alpha-tocopherol and pure tocotrienol on bone microarchitecture and cellular parameters in ovariectomi...
متن کاملPostmenopausal osteoporosis and tooth loss.
OBJECTIVE The aim of this study was to determine relation between tooth loss and general body bone mineral density in postmenopausal female who were seeking for prosthetic treatment. MATERIAL AND METHODS There were included 79 women in this study (age from 49-81 years, mean age 62.9 years) with partial tooth loss. For all patients bone mineral density measurements for lumbar spine and both fe...
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OBJECTIVE To examine the role of peak bone mass and subsequent postmenopausal bone loss in the development of osteoporosis and the reliability of identifying women at risk from one bone mass measurement and one biochemical assessment of the future bone loss. DESIGN Population based study. SETTING Outpatient clinic for research into osteoporosis. SUBJECTS 178 healthy early postmenopausal w...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2017
ISSN: 0736-0266
DOI: 10.1002/jor.23643